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KMID : 0438420140210030189
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Korean Journal of Bone Metabolism
2014 Volume.21 No. 3 p.189 ~ p.194
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High Dietary Sodium Intake Assessed by 24-hour Urine Specimen Increase Urinary Calcium Excretion and Bone Resorption Marker
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Park Sun-Mi
Jee Jae-Hwan
Joung Ji-Young
Cho Yoon-Young
Sohn Seo-Young
Jin Sang-Man
Hur Kyu-Yeon
Kim Jae-Hyeon
Kim Sun-Wook
Chung Jae-Hoon
Lee Moon-Kyu
Min Yong-Ki
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Abstract
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Background: The average dietary sodium intake of Koreans is 2.6 times higher than the World Health Organization’s recommended amount. The effect of a diet high in sodium on the skeletal system, especially osteoporosis, has not previously been examined in Korean postmenopausal women with low bone mass. We assessed the daily sodium intake, and determined the impact of sodium intake on urinary calcium excretion and bone resorption marker.
Methods: A retrospective review of medical records was performed for 86 postmenopausal subjects who were initially diagnosed with osteopenia or osteoporosis at the health promotion center. They were subsequently referred to the Division of Endocrinology and Metabolism between 2010 and 2013. All subjects completed a modified food frequency questionnaire. Twenty-four hour urine collection for sodium, calcium and creatinine excretion, and serum C-terminal telopeptides of type I collagen (CTX-I) were also obtained.
Results: The average amount of daily sodium and calcium intake were 3,466 mg and 813 mg, respectively. Average dietary sodium intake and 24-hour urinary sodium excretion showed significant positive linear correlation (r=0.29, P=0.006). There was also a significant positive linear correlation between 24-hour urine sodium and calcium excretion (r=0.42, P<0.001); CTX-I and 24-hour urinary calcium excretion (r=0.29, P=0.007).
Conclusions: Excessive sodium intake assessed by 24-hour urine specimen is associated with high calcium excretion in urine. High calcium excretion is also related to increasing bone resorption marker.
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KEYWORD
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Bone resorption marker, Dietary sodium intake, Urinary calcium excretion, Urinary sodium excretion
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